Purchased every slot in all four Plasmid and Tonic tracks

The player has completed Sander Cohen's great masterpiece

The player has purchased every slot in one of the Plasmid or Tonic tracks

Fully research the Nitro Splicer

Fully research the Houdini Splicer

The player has successfully invented all possible ammo types

The player has fully upgraded one weapon

The player has successfully invented at least one item

The player has defeated Peach Wilkins

The player has fully researched the Leadhead Splicer

The player has taken a Research Photo of the highest grade

The player has successfully hacked a security camera

The player has successfully hacked a safe