Beat Greed Mode with Azazel

Kill Mom's Heart 5 times

Beat the Womb/Utero without taking damage

Have 7 or more max red hearts at one time

Kill Satan

Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball

Beat the Depths/Necropolis without taking damage

Hold 55 or more pennies at one time

Have 4 or more soul hearts at one time

Beat the Basement/Cellar without taking damage

Clear the Dream Warehouse Trial (Hard) in the Realm of Eureka within 120 seconds

Collect 250 Whimstars