Beat Cathedral 5 times

Beat the Dark Room

Beat Sheol 5 times

Beat the Basement/Cellar without taking damage

Kill Isaac with Isaac

Beat the Depths 20 times

Kill Satan with Eve

Kill Satan

As a Peashooter, vanquish 10 Players with the Pea Gatling in a session

Vanquish 500 Pirate Zombies

Have 7 or more max red hearts at one time

Defuse a Gnome Bomb with Less Than 3 Seconds Remaining

Kill Mom