The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has broken Fontaine's mind control

The player has defeated Andrew Ryan

The player has completed Sander Cohen's great masterpiece

The player has fully upgraded one weapon

The player has purchased one slot in any Plasmid or Tonic track

The player has defeated Peach Wilkins

The player has taken at least one Research Photo of a Splicer

The player has successfully hacked a safe

The player has successfully hacked a turret

The player has successfully hacked a security bot

The player has shocked an enemy in the water