Conquered the Reaper.

Finish Shadows of Rose on at least Standard difficulty.

Use Rose's mutamycete powers at least 20 times.

Create all items that contain Chem Fluid and Strong Chem Fluid.

Shoot and knock back Marguerite while she's leaping at you.

Increase your item slots.

Finish off an enemy with the knife.

Avoid Jack's scissor attack by crouching.

Complete the "Mia" videotape without being spotted by Marguerite.

Block an enemy attack by guarding.

Use a lock pick to open something.

Obtain something by closely examining an item.