Complete the game on Hard difficulty without using a Vita-Chamber.

The player has completed the game without harvesting any Little Sisters

Hit the jackpot at a slot machine

Find every audio diary

Acquire all upgrades for all weapons

Fully upgrade five weapons

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has taken a picture of Sander Cohen's corpse

The player has successfully invented all possible ammo types

Fully research the Nitro Splicer

The player has defeated Andrew Ryan

Fully research the Bouncer

The player has fully upgraded three weapons