The player has become a Big Daddy

The player has either Harvested or Rescued every possible Little Sister

Fully upgrade five weapons

The player has broken Fontaine's mind control

The player has entered Sander Cohen's personal quarters

Fully upgrade four weapons

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has successfully invented all possible ammo types

The player has fully upgraded three weapons

The player has completed Sander Cohen's great masterpiece

The player has fully upgraded two weapons

Hit the jackpot at a slot machine

Fully research the Rosie