The player has completed the game on the Hard difficulty setting

Complete the game on Hard difficulty without using a Vita-Chamber.

Hit the jackpot at a slot machine

The player has completed the game without harvesting any Little Sisters

Acquire all upgrades for all weapons

The player has taken a picture of Sander Cohen's corpse

The player has become a Big Daddy

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

Fully upgrade four weapons

The player has successfully completed 50 hacks

Fully research the Nitro Splicer

Fully research the Little Sister

The player has defeated Andrew Ryan