Go 10 seconds of the match without being hit by your opponent

Defeat 50 Enemies with Hand-to-Hand Combat

Kill 5 Enemies in a Row with Headshots

Find all Treasures and the Strange Relic

Finish the Game on Brutal Without Changing the Difficulty

Kill 20 Enemies by Shooting from the Hip (without aiming)

Find 50 Treasures

Kill an Enemy While Playing as an Alternate Character Costume Other Than Drake

Find 1 Treasure

Obtain all the Trophies.

Gather a total of 60 relics.

Craft a special syringe.

Gather all the memory cards.