Beat 3 victory laps in one run

Beat the Dark Room with Isaac

Kill Satan with Cain

Kill Satan with Lazarus

Beat the Basement 40 times

Slay your first boss

First party wipe

Have a character survive 5 attacks at Death's Door in a single combat

Complete The First Farmstead Quest

Kill 50 enemies with one hero

Dismiss your first hero

Lose your first hero to heart attack

Abandon a quest