The player has broken Fontaine's mind control

Fully upgrade four weapons

The player has taken a picture of Sander Cohen's corpse

Fully research the Nitro Splicer

The player has defeated Andrew Ryan

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

Fully research the Little Sister

The player has completed Sander Cohen's great masterpiece

The player has fully upgraded two weapons

Hit the jackpot at a slot machine

The player has restored the forests of Arcadia

Fully research the Houdini Splicer