The player has become a Big Daddy

Acquire all upgrades for all weapons

The player has broken Fontaine's mind control

The player has entered Sander Cohen's personal quarters

Purchased every slot in all four Plasmid and Tonic tracks

The player has purchased every slot in one of the Plasmid or Tonic tracks

Hit the jackpot at a slot machine

The player has completed Sander Cohen's great masterpiece

The player has fully researched the Spider Splicer

Take at least one photo in every research group

Fully research the Rosie

The player has fully upgraded one weapon

The player has fully researched the Thuggish Splicer