The player has broken Fontaine's mind control

The player has entered Sander Cohen's personal quarters

The player has fully upgraded two weapons

Fully research the Little Sister

The player has purchased every slot in one of the Plasmid or Tonic tracks

Fully research the Bouncer

The player has completed Sander Cohen's great masterpiece

The player has successfully invented all possible ammo types

Take at least one photo in every research group

Fully research the Houdini Splicer

The player has successfully invented at least one item

The player has acquired at least one weapon upgrade

The player has taken a Research Photo of the highest grade