Save Chris from confinement using Jill.

Break into the laboratory using Jill.

Defeat Yawn using Jill.

Obtain the Helmet Key using Jill.

Defeat a Crimson Head prototype1 using Jill.

Save Jill using Barry.

Defeat a Crimson Head.

Defeat a zombie.

Finish Leech Hunter with rank A.

Defeat Queen Leech.

Obtain all keys and use them all.

Defeat Mimicry Marcus with a Molotov Cocktail or a Napalm Grenade.

Fight off the Proto Tyrant.