Fully upgrade a weapon

Kill 5 guards with one use of Assassin's Focus

Complete a Tale from Baghdad

Headshot 20 guards with throwing knives

Tag 100 guards using Enkidu

At maximum notoriety, become anonymous by tearing down wanted posters

Become an Initiate of the Hidden Ones

Take Songbird to the stars.

Complete all Cyberpsycho Sightings.

Kill or incapacitate an enemy who threw a grenade at you.

Collect all items that once belonged to Johnny Silverhand.

Save President Myers.

Perform the Distract Enemies quickhack 30 times without drawing attention to yourself.