The player has become a Big Daddy

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

Acquire all upgrades for all weapons

Fully research the Rosie

Fully research the Nitro Splicer

The player has taken a picture of Sander Cohen's corpse

The player has defeated Andrew Ryan

Fully research the Bouncer

The player has completed Sander Cohen's great masterpiece

Take at least one photo in every research group

The player has fully researched the Spider Splicer

The player has successfully hacked a vending machine