The player has completed the game without harvesting any Little Sisters

Successfully invent at least 100 items

The player has become a Big Daddy

Acquire all upgrades for all weapons

The player has broken Fontaine's mind control

The player has taken a picture of Sander Cohen's corpse

Fully upgrade four weapons

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has defeated Andrew Ryan

The player has fully upgraded three weapons

The player has completed Sander Cohen's great masterpiece

Take at least one photo in every research group

Hit the jackpot at a slot machine