The player has defeated Atlas

The player has either Harvested or Rescued every possible Little Sister

The player has fully upgraded three weapons

The player has broken Fontaine's mind control

Fully research the Little Sister

Fully research the Rosie

The player has defeated Andrew Ryan

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has completed Sander Cohen's great masterpiece

The player has restored the forests of Arcadia

The player has acquired at least one weapon upgrade

The player has successfully completed 50 hacks

The player has taken a Research Photo of the highest grade