The player has acquired at least one weapon upgrade

Fight off Marguerite while she wanders the old house to make her run away.

Take down two or more enemies with one shot.

Escape to the yard.

Use a lock pick to open something.

The player has taken a Research Photo of the highest grade

The player has purchased one slot in any Plasmid or Tonic track

Put an unrelated object on a shadow plinth.

Obtain something by closely examining an item.

Escape from the guest house.

Travel to Louisiana.

The player has successfully hacked a vending machine

The player has defeated the crazed Dr. Steinman