Beneath the arthropod

Craft every item

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

Acquire all upgrades for all weapons

The player has completed the game without harvesting any Little Sisters

The player has become a Big Daddy

Fully upgrade four weapons

Purchased every slot in all four Plasmid and Tonic tracks

Max out all possible research

The player has fully upgraded three weapons

The player has defeated Andrew Ryan

Fully research the Little Sister

The player has taken a picture of Sander Cohen's corpse