The player has broken Fontaine's mind control

Fully research the Little Sister

The player has fully upgraded three weapons

The player has fully upgraded two weapons

The player has purchased every slot in one of the Plasmid or Tonic tracks

After getting hit by a pitch, hit a home run on that player's following at-bat (only earned if playing an uninterrupted game against the CPU, without switching sides or fast forwarding).

The player has completed Sander Cohen's great masterpiece

The player has fully researched the Spider Splicer

The player has fully upgraded one weapon

The player has fully researched the Leadhead Splicer

The player has acquired at least one weapon upgrade

The player has taken at least one Research Photo of a Splicer