Acquire all upgrades for all weapons

The player has broken Fontaine's mind control

The player has entered Sander Cohen's personal quarters

Fully upgrade four weapons

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

Fully research the Little Sister

Purchased every slot in all four Plasmid and Tonic tracks

The player has completed Sander Cohen's great masterpiece

The player has fully upgraded two weapons

The player has successfully invented all possible ammo types

The player has restored the forests of Arcadia

The player has fully upgraded one weapon