Successfully invent at least 100 items

The player has defeated Atlas

The player has either Harvested or Rescued every possible Little Sister

Purchased every slot in all four Plasmid and Tonic tracks

Fully upgrade four weapons

The player has defeated Andrew Ryan

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has completed Sander Cohen's great masterpiece

The player has fully upgraded one weapon

The player has successfully invented at least one item

The player has purchased one slot in any Plasmid or Tonic track

The player has defeated Peach Wilkins