Successfully invent at least 100 items

The player has broken Fontaine's mind control

The player has entered Sander Cohen's personal quarters

Take at least one photo in every research group

Purchased every slot in all four Plasmid and Tonic tracks

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has completed Sander Cohen's great masterpiece

The player has fully upgraded two weapons

The player has fully researched the Spider Splicer

The player has restored the forests of Arcadia

Fully research the Houdini Splicer

The player has fully researched the Thuggish Splicer

The player has successfully completed 50 hacks