Clear Arcade Mode without using a single continue on Medium or higher difficulty.

Perform 100 Special Moves.

Complete the game on Hard difficulty without using a Vita-Chamber

Acquire all upgrades for all weapons

The player has entered Sander Cohen's personal quarters

Fully research the Houdini Splicer

The player has completed the game without harvesting any Little Sisters

The player has become a Big Daddy

Fully upgrade four weapons

The player has broken Fontaine's mind control

Fully research the Nitro Splicer

Purchased every slot in all four Plasmid and Tonic tracks