The player has fully upgraded three weapons

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has fully upgraded one weapon

The player has fully researched the Thuggish Splicer

The player has completed Sander Cohen's great masterpiece

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has successfully invented all possible ammo types

Earn 10 Tetris Line Clears.

Clear 100 Lines.

The player has successfully completed 50 hacks

Activate the Zone mechanic.

The player has fully researched the Leadhead Splicer

The player has defeated Peach Wilkins