In the Main Campaign, equipped a piece of Gear in all four slots.

The player has completed the game without harvesting any Little Sisters

The player has become a Big Daddy

The player has either Harvested or Rescued every possible Little Sister

Fully upgrade four weapons

The player has fully upgraded three weapons

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has fully upgraded one weapon

The player has completed Sander Cohen's great masterpiece

The player has successfully invented at least one item

The player has defeated Peach Wilkins

The player has taken at least one Research Photo of a Splicer

The player has purchased one slot in any Plasmid or Tonic track