Beat your first Arty Alligator and move on to the next area

Finish a Stage with The Janitor

Use the Combo Time Buff for the first time

Use the Vitality Buff for the first time

Use the Charge Attack for the first time

Defeat Her.

Reach Room 312.

Reach the Lakeview Hotel.

Find His room.

Kill at least one enemy with Wooden Plank, Steel Pipe, Handgun, Shotgun and Rifle in a single playthrough.

Reach the end of the long staircase.

Defeat the Flesh Lip.