Increase your item slots.

Avoid Jack's scissor attack by crouching.

Use psychostimulants.

Use a lock pick to open something.

Destroy a Mr. Everywhere statuette.

Escape from the guest house.

Obtain something by closely examining an item.

Complete Liberation.

Complete S.O.E.

Defeat 100 Afflicted in the main campaign.

Have Moira stun an enemy and Claire follow up with a physical attack in the main campaign.

Complete Operation Cobra.

Bought your first car