ME2: Hit 20 different targets with multiple biotic powers to combine the effects

ME2: Gain the loyalty of the Professor

ME2: Thresher Maw defeated

ME2: Gain the loyalty of the Cerberus Operative

Connected a Counterattack.

ME2: Visit 100% of the planets in an unexplored cluster

ME2: Gain the loyalty of the mercenary

ME2: Evolve any power

ME2: Successfully recruit the biotic Convict

ME2: Complete a mission discovered by scanning an unexplored world

Complete Claire's story.

Open all of the safes and locks in the game.