Dealt with every Little Sister.

Fully upgraded one Plasmid to the Level 3 version.

Defeated the Preacher.

Spent 2000 dollars at Vending Machines.

Confronted Lamb's lieutenant in Pauper's Drop.

Researched a Splicer with the Research Camera.

Defended yourself against the Big Sister without dying.

Upgraded a weapon at a Power to the People Station.

Used the Hack Tool to hack an object at a distance.

The player has defeated Atlas

The player has become a Big Daddy

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has defeated Andrew Ryan