Saved every Little Sister and spared Grace, Stanley and Gil.

Dealt with every Little Sister.

Uncovered the secret of Dionysus Park.

Defeated the Preacher.

Bought one Plasmid or Tonic Slot at a Gatherer's Garden.

Installed the third upgrade to a weapon.

Joined forces with Sinclair in Ryan Amusements.

Hacked one of each kind of machine.

Upgraded a weapon at a Power to the People Station.

Used the Hack Tool to hack an object at a distance.

Reach Commander (Level 55) in Multiplayer while playing online

The player has completed the game without harvesting any Little Sisters