Take down Zsasz in the Patient Pacification Chamber

Defeat 4th Colossus

Defeat 2nd Colossus

Defeat 20 enemies with hand-to-hand combat

Kill 100 enemies with melee attacks.

Kill 5 enemies with Blood Frenzy in a single campaign game or multiplayer match.

Mission accomplished.

Defeat an old adversary.

Finish all multiplayer maps or all N7 missions in single-player.

Kill 1,000 enemies.

Complete three multiplayer matches or five N7 missions.

Establish or rekindle a romantic relationship.