The player has completed the game on the Hard difficulty setting

Fully research the Little Sister

The player has fully researched the Leadhead Splicer

Fully upgrade four weapons

Purchased every slot in all four Plasmid and Tonic tracks

The player has fully researched the Spider Splicer

The player has become a Big Daddy

The player has fully upgraded three weapons

The player has defeated Andrew Ryan

The player has completed Sander Cohen's great masterpiece

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has successfully completed 50 hacks

The player has acquired at least one weapon upgrade