Max out all possible research

Fully research the Little Sister

Fully research the Bouncer

The player has purchased every slot in one of the Plasmid or Tonic tracks

Take at least one photo in every research group

Hit the jackpot at a slot machine

The player has successfully invented all possible ammo types

Fully research the Rosie

The player has fully upgraded one weapon

The player has successfully invented at least one item

The player has fully researched the Leadhead Splicer

The player has successfully completed 50 hacks

The player has taken at least one Research Photo of a Splicer