The player has broken Fontaine's mind control

Fully upgrade four weapons

The player has defeated Andrew Ryan

Purchased every slot in all four Plasmid and Tonic tracks

Fully research the Bouncer

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has taken a picture of Sander Cohen's corpse

Take at least one photo in every research group

The player has fully researched the Spider Splicer

The player has successfully invented at least one item

Fully research the Houdini Splicer

The player has fully researched the Thuggish Splicer

The player has defeated Peach Wilkins