Got all puzzle pieces in Memory Meadow.

Got all artifacts in Cooling Springs.

Increase your inventory slots.

Open a dial safe.

Counterattack with a sub-weapon.

Combine two items together.

Escape from uptown Raccoon City.

Make it to the police station.

Perform 20 auto combos. (Arcade/online only)

Complete 20 missions in Mission Mode.

Kill 5 Enemies in a Row with Headshots

Kill an Enemy While Playing as an Alternate Character Costume Other Than Drake

Kill 10 Enemies in a Row with a Single Punch After Weakening Them with Gunfire