Activated 20 or more abilities in one song

Achieved first Perfect Chain

Kill Hush for the first time

Kill Satan with The Lost

Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball

Kill Isaac with The Lost

Beat the Womb for the first time

Beat Sheol 5 times

Kill Satan with Eden

Beat 2 levels in a row without taking damage

Kill Satan with Azazel

Kill Isaac with Lazarus

Have 4 or more soul hearts at one time