The player has purchased every slot in one of the Plasmid or Tonic tracks

Fully research the Rosie

Fully research the Bouncer

The player has become a Big Daddy

Take at least one photo in every research group

The player has broken Fontaine's mind control

The player has entered Sander Cohen's personal quarters

The player has defeated Andrew Ryan

The player has purchased one slot in any Plasmid or Tonic track

The player has fully researched the Leadhead Splicer

The player has successfully invented all possible ammo types

The player has fully researched the Thuggish Splicer

The player has restored the forests of Arcadia