Kill Isaac with The Lost

Kill Satan with ???

Beat the Womb for the first time

Beat Sheol 5 times

Collect all items and unlock all secrets and endings

Beat 2 levels in a row without taking damage

Kill Isaac with Lazarus

Have 4 or more soul hearts at one time

Make 3 deals with the devil in one run

Kill Isaac with Judas

Kill Mom's Heart 5 times

Kill all 7 sins

Kill Satan with Isaac