The player has completed Sander Cohen's great masterpiece

Complete the game on Easy

Craft every item

The player has successfully invented all possible ammo types

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has fully researched the Thuggish Splicer

Complete a game of Supply Raid on Bookstore, Home Town, Suburbs or Bus Depot

Complete a game of Supply Raid on Wharf, Capitol, Water Tower or Coal Mine

The player has defeated Peach Wilkins

The player has fully researched the Leadhead Splicer

The player has taken at least one Research Photo of a Splicer

The player has defeated the crazed Dr. Steinman