The player has defeated Atlas

Find every audio diary

Acquire all upgrades for all weapons

Successfully invent at least 100 items

The player has broken Fontaine's mind control

The player has entered Sander Cohen's personal quarters

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

Purchased every slot in all four Plasmid and Tonic tracks

The player has purchased every slot in one of the Plasmid or Tonic tracks

Fully research the Bouncer

Take at least one photo in every research group

The player has fully researched the Spider Splicer