The player has broken Fontaine's mind control

The player has entered Sander Cohen's personal quarters

Max out all possible research

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has defeated Andrew Ryan

Fully research the Bouncer

The player has completed Sander Cohen's great masterpiece

Fully research the Little Sister

The player has fully upgraded one weapon

Hit the jackpot at a slot machine

The player has restored the forests of Arcadia

Fully research the Rosie

The player has fully researched the Thuggish Splicer