The player has completed the game on the Hard difficulty setting

The player has defeated Atlas

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

Acquire all upgrades for all weapons

Max out all possible research

The player has broken Fontaine's mind control

The player has entered Sander Cohen's personal quarters

The player has defeated Andrew Ryan

Fully research the Bouncer

Take at least one photo in every research group

The player has fully upgraded two weapons

Hit the jackpot at a slot machine