Spent 2000 dollars at Vending Machines.

Installed the third upgrade to a weapon.

Defeated 3 Big Daddies without dying during the fight.

Confronted Lamb's lieutenant in Pauper's Drop.

Joined forces with Sinclair in Ryan Amusements.

Bought one Plasmid or Tonic Slot at a Gatherer's Garden.

Upgraded a weapon at a Power to the People Station.

Used the Hack Tool to hack an object at a distance.

Rescued the Little Sister in “The ‘I’ in Team”

The player has either Harvested or Rescued every possible Little Sister

Fully research the Little Sister

Fully upgrade four weapons

Fully research the Nitro Splicer