Fully research the Rosie

The player has fully upgraded three weapons

The player has taken a picture of Sander Cohen's corpse

The player has fully upgraded two weapons

You did what the wind couldn't.

The player has fully researched the Spider Splicer

Hit the jackpot at a slot machine

The player has restored the forests of Arcadia

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has fully researched the Thuggish Splicer

The player has successfully invented at least one item

The player has defeated Peach Wilkins