The player has purchased every slot in one of the Plasmid or Tonic tracks

Fully research the Nitro Splicer

The player has fully upgraded two weapons

The player has fully researched the Spider Splicer

Hit the jackpot at a slot machine

Fully research the Rosie

Fully research the Houdini Splicer

The player has successfully invented at least one item

The player has defeated Peach Wilkins

The player has taken at least one Research Photo of a Splicer

The player has purchased one slot in any Plasmid or Tonic track

The player has successfully hacked a safe