Max out all possible research

The player has entered Sander Cohen's personal quarters

Fully upgrade four weapons

Fully research the Nitro Splicer

Fully research the Bouncer

Purchased every slot in all four Plasmid and Tonic tracks

The player has fully upgraded two weapons

The player has fully upgraded one weapon

The player has successfully invented all possible ammo types

The player has restored the forests of Arcadia

The player has fully researched the Leadhead Splicer

The player has purchased every slot in one of the Plasmid or Tonic tracks

The player has acquired at least one weapon upgrade