Complete the game on Survivor difficulty

Found all collectable Roses in “Worlds of Hurt”

Rescued the Little Sister in “Worlds of Hurt” using only plasmids, tonics, the wrench, and the research camera, on Medium or higher difficulty

The player has rescued the Little Sister in “A Shocking Turn of Events” in under 4:00

Found all collectable Roses in “A Shocking Turn of Events”

Rescued the Little Sister in “The ‘I’ in Team” without destroying any Machine Gun Turrets

Rescued the Little Sister in “The ‘I’ in Team”

The player has completed the game without harvesting any Little Sisters

The player has become a Big Daddy

The player has either Harvested or Rescued every possible Little Sister

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

Successfully invent at least 100 items