Find every audio diary

Max out all possible research

The player has completed the game on the Hard difficulty setting

Complete the game on Hard difficulty without using a Vita-Chamber.

The player has completed the game without harvesting any Little Sisters

The player has successfully invented all possible ammo types

The player has either Harvested or Rescued every possible Little Sister

Acquire all upgrades for all weapons

Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks

The player has broken Fontaine's mind control

The player has entered Sander Cohen's personal quarters

Fully research the Rosie